Tetherin restricts productive HIV-1 cell-to-cell transmission.
The IFN-inducible antiviral protein tetherin (or BST-2/CD317/HM1.24) impairs release of mature HIV-1 particles from infected cells.HIV-1 Vpu antagonizes the effect of tetherin.The fate of virions Fashion Accessories trapped at the cell surface remains poorly understood.Here, we asked whether tetherin impairs HIV cell-to-cell transmission, a major m